Hydrabio H2O

• Contains the patented AQUAGENIUM™, proprietary complex that stimulates the Aquaporins synthesis (+55% increase in ARMm) ⁽¹⁾
• Removes impurities and pollution particles ⁽²⁾
• Removes make-up from face and eyes ⁽³⁾
• Moisturizes, increases hydration rate by +17.4% after 8h ⁽⁴⁾.
• Leaves the skin comfortable

Good cutaneous and ocular tolerance – No rinsing – Non-greasy – Non-shiny ⁽⁵⁾

Clinically tested on patients with sensitive combination, normal, dry and very dry skin, using make-up. ^(2,3,4,5) 

(1)In vitro test on keratinocytes – evaluation of Aquaporine-3 synthesis by Pyrus Malus fruit extract (0.1%) - RT-PCR analysis
(2)In vivo evaluation of Hydrabio H2O cleansing efficacy toward pollution particles – 20 volunteers (aged 18 - 65 year) with sensitive skin, living in polluted environment - Dsquam and image acquisition through SEM scanning electron microscopy – Immediate measure. Italie. 2018
(3)In vivo evaluation of cleansing and make-up removing power of Hydrabio H2O – 10 volunteers (aged 24 to 42 years old) - Chromameter – Immediate measure. France. 2014
(4)In vivo evaluation of moisturizing performance of Hydrabio H2O, double-blind study - 10 volunteers (aged 26 - 65 years old) with dry or moderately hydrated skin with only one application. France. 2015
(5)Use test on Hydrabio H2O – 20 patients (aged 19 to 45), with sensitive, fragile, and dehydrated skin with only one application. France.2014

> CLINICAL RESULTS

The AquageniumTM patented complex helps the skin to reconstitute its own resources and restore its original hydrating abilities. This complex contains active ingredients that: (1)

• improve the hydric flows by stimulating Aquaporin-3 synthesis thanks to Pyrus Malus fruit extract. An in vitro study was conducted on keratinocytes. After addition of Pyrus Malus fruit extract, an RT-PCR analysis showed an increase in ARMm synthesis coding for Aquaporin-3. (+55% synthesis vs control)
• restore the lipids that bond the corneocytes and thus improve the horny layer’s impermeability.

Hydrabio H20 shows a high cleansing power:

• very good pollen removing efficacy, with 99.8%* measured efficacy on removing pollen grains ⁽²⁾
• pollution particle cleansing efficacy: removes heavy metals (Zinc, Nickel, Lead) from the skin bringing back to the basal levels their concentration, after 6 hours of pollutant exposure. ⁽³⁾
• elimination of 71.6% of mascara demonstrates high make up removing power ⁽⁴⁾

Hydrabio H2O has an excellent moisturizing power as it increases skin hydration rate by 23.8% in 1 hour after application, 26.6% in 3 hours, 21.6% in 6 hours and 17.4% in 8 hours. ⁽⁵⁾

TOLERANCE
Ocular and cutaneous tolerance of Hydrabio H2O were evaluated as very good by the dermatologists. No effects were reported during the application of the product. ⁽⁶⁾

*p<0.001 Paired T-test

> PATIENTS FEEDBACKS
After 7 days of using Hydrabio H2O under normal conditions of use:

• 95% of patients reported that their skin was properly cleansed, comfortable, and more supple. ⁽⁶⁾
• More than 80% of them reported that the product did not leave a sticky film and had a pleasant texture ⁽⁶⁾
• More than 90% of them reported the “gentleness” of the cleansing process and the ease of application. ⁽⁶⁾

(1)In vitro test on keratinocytes – evaluation of Aquaporine-3 synthesis by Pyrus Malus fruit extract (0.1%) - RT-PCR analysis
(2)In vivo evaluation of Sensibio H2O cleansing efficacy toward pollen particles – 20 volunteers aged 22 to 67 years -Measure of heavy metals concentration on skin with Atomic Absorption Spectrometry method, after 6 hours in city traffic.  France. 2019
(3)In vivo evaluation of Hydrabio H2O cleansing efficacy toward pollution particles – 20 volunteers (aged 18 - 65 year) with sensitive skin, living in polluted environment - Dsquam and image acquisition through SEM scanning electron microscopy – Immediate measure. Italie. 2018
(4)In vivo evaluation of cleansing and make-up removing power of Hydrabio H2O – 10 volunteers (aged 24 to 42 years old) - Chromameter – Immediate measure. France. 2014
(5)In vivo evaluation of moisturizing performance of Hydrabio H2O, double-blind study - 10 volunteers (aged 26 - 65 years old) with dry or moderately hydrated skin with only one application. France. 2015
(6)Use test on Hydrabio H2O – 20 patients (aged 19 to 45), with sensitive, fragile, and dehydrated skin with only one application. France.2014