Management of post-procedure wound healing with a new skin healing dermocosmetic based on an ecobiological approach

Applying an adapted moisturizer during the healing process after aesthetic procedures is commonly practiced to help wound healing, to reduce discomfort sensations, and most importantly, the final issue, to lead to absence of pigmented scar. In this context, an in vitro study, four experimental studies and a clinical study were carried out to evaluate the healing effect of a new dermocosmetic product according to the ecobiological approach which considers the skin as a living ecosystem in interface with its internal and external environment, and whose natural biology must be protected.

The active ingredients efficacy was evaluated on injured reconstructed human skin. The protective skin barrier function and breathing effect of the product was investigated via TEWL studies and by measuring the transcutaneous O2 and CO2 partial pressures (radiometer). Then skin microbiome was analyzed via 16S rRNA gene sequencing after disinfection. Finally, the tolerance and efficacy of the product (half-face 2x/14 days) were evaluated after peeling (glycolic acid 70%) in a comparative clinical study (overall scar score of 3 sub-scores: inflammation, scar appearance, soothing effect).

In vitro, the active ingredients improved re-epithelialization, speed of wound closure (D7 91% vs 48% for untreated) and healing quality. A significant improvement of the TEWL was observed after application of blotting paper (20.9%) and after rubbing (11.7%), without variation in transcutaneous O2 and CO2 pressures. The microbiome analysis showed a diversity restoration from 3hrs after disinfection, contrary to the control. Finally, a significant reduction of the overall scar score vs placebo was observed at D3 vs D0 (-56% vs -32%) and D7 (-81% vs -55%) after peeling, with no adverse event.