Assessment of the efficacy and tolerance of an innovative regenerative serum on cutaneous regeneration, following fractional laser procedure using Erbium: YAG

Authors: Natalia Jiménez, Angela Hermosa, Laura de Miguel, Natalia Sánchez-Neila, Maria Teresa Truchuelo, Itziar Eraña, Jesus Cuevas

First published: 22 January 2018

Original Publication from the Journal of Cosmetic Dermatology (JDC), Impact factor (2021): 2.189

Written by

Natalia Jiménez In collaboration with 6 others professionals

Related topics

Aesthetics / Ageing

Prospective, double-blind, controlled, and randomized study in subjects with photoaged skin. The regenerative serum of treatment was used after a fractional laser session twice daily for 2 months on 1 side of the face and the placebo on the other side. The main variable to determine efficacy was the improvement of clinical signs and histological and immunological results.

A superior quality of epidermal regeneration on the treated side compared to the placebo side was observed. Likewise, a superior and faster clinical improvement on static wrinkles was observed on the hemiface on which the regenerative serum was used. After 60 days, the investigator and the subjects observed a moderate to significant improvement of the skin on the treated side and a mild to moderate improvement on the placebo side.

Histological examinations showed a superior thickness of epidermis and higher cellular proliferation rate (Ki67 markers) as well as a superior thickness of dermis with higher increase in elastin density with the regenerative serum compared to placebo.

Assessment of the efficacy and tolerance of an innovative regenerative serum on cutaneous regeneration, following fractional laser procedure using Erbium: YAG

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