Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by dry skin and itches with flare-ups. Frequently appearing in the early childhood, it affects approximately 20% of children and 3% of adults worldwide(1). The pathogenesis of AD is multifactorial, including an imbalanced immune system signaling, an impaired skin barrier, and the dysbiosis of the skin microbiome. Recent research has shown that Staphylococcus aureus (S. aureus) represents the major bacterial species in the impaired skin microbiome of AD lesions(2,3). It colonizes skin patients in the form of a biofilm(4-8). This microenvironment helps bacteria to protect themselves from phagocytosis, antibiotics, antimicrobial peptides, thus enabling chronic persistence in the host(9-11) and influencing the severity of AD(12).